SIMIAN LINE & HEALTH - Simian crease in medical problems!

NOTICE: Quite some of the data above is summarized in:

- Hautleistenfibel, A. Rodewald (1981)
- Dermatoglyphics in Medical Disorders, Schaumann & Alter (1976)


Other more rare syndromes that are linked with the simian line are e.g.:

• Aarskog-Scott syndrome;
• cri-du-chat syndrome (cat-cry) [5p-] - 82.2 %;
• Cohen syndrome;
• Cornelia de Lange syndrome - 65.2 %;
• fetal alcohol syndrome;
• Kabuki syndrome - 18 %;
• Noonan syndrome;
• Patau syndrome [trisomy 13] - 59.5 %;
• Poland syndrome;
• Rubella syndrome;
• Rubinstein-Taybi syndrome - 39.0 %;
• Seckel syndrome;
• Smith-Lemli-Opitz syndrome - 78.4 %;
• Warkany syndrome [trisomy 8] - 37.5 %, 47.1 %;
• Williams-Beuren syndrome;
• Wolf-Hirschhorn syndrome - 52.3 %;
• Zellweger syndrome;
• 18p-, 18q- and 18r syndrome - 14.3 %, 44.8 %, 13.0 %.

Beyond these syndromes (which are usally caused by- or featured with genetic aberations), the simian line has also been related to various (non-)genetic diseases such as: diabetes mellitus (type 1 & 2), familial deafness, leprosy, and rheumatoid arthritis.

Also, the simian is more common in psychiatric populations such as seen in: schizophrenia (psychotic disorders) & ADHD.

But this doesn't implicate that the simian line can be associated with any diseases. For example, auto-immune diseases (which typically have a higher occurence in females than in males) are generally not associated with a higher occurence of the simian line (which is more common in males). Though the hand in diabetes mellitus type 1 could be the exception that confirms the rule!

Next section:
• Psychology & behavior: the simian line!

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